University of Manchester, Manchester, United Kingdom

University of Manchester Wolfson Molecular Imaging Centre (WMIC), University of Manchester Centre for Clinical Neuroscience

[Group description | Scientific staff | Publications within DiMI]

References

Imaging Alzheimer’s Disease

  1. Herholz K, Schopphoff H, Schmidt M, Mielke R, Eschner W, Scheidhauer K, Schicha H, Heiss WD, Ebmeier K. Direct comparison of spatially normalized PET and SPECT scans in Alzheimer's disease. J Nucl Med 2002;43:21-6.
  2. Herholz K, Salmon E, Perani D, Baron JC, Holthoff V, Frolich L, Schonknecht P, Ito K, Mielke R, Kalbe E, Zundorf G, Delbeuck X, Pelati O, Anchisi D, Fazio F, Kerrouche N, Desgranges B, Eustache F, Beuthien-Baumann B, Menzel C, Schroder J, Kato T, Arahata Y, Henze M, Heiss WD. Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET. Neuroimage 2002;17:302-16.
  3. Herholz K, Lercher M, Wienhard K, Bauer B, Lenz O, Heiss WD. PET measurement of cerebral acetylcholine esterase activity without blood sampling. Eur J Nucl Med 2001;28:472-7.
  4. Herholz K, Bauer B, Wienhard K, Kracht L, Mielke R, Lenz MO, Strotmann T, Heiss WD. In-vivo measurements of regional acetylcholine esterase activity in degenerative dementia: comparison with blood flow and glucose metabolism. J Neural Transm 2000;107:1457-68.

Imaging using PK11195

  1. Banati, R. B., A. Cagnin, et al. (2001). "Long-term trans-synaptic glial responses in the human thalamus after peripheral nerve injury." Neuroreport 12(16): 3439-42.
  2. Banati, R. B., G. W. Goerres, et al. (1999). "[11C](R)-PK11195 positron emission tomography imaging of activated microglia in vivo in Rasmussen's encephalitis." Neurology 53(9): 2199-2203.
  3. Cagnin, A., D. J. Brooks, et al. (2001). "In-vivo measurement of activated microglia in dementia." Lancet 358: 461-467.   
  4. Cagnin, A., R. Myers, et al. (2001). "In-vivo visualisation of activated glia by [C] (R)-PK 11195-PET following herpes encephalitis reveals projected neuronal damage beyond the primary focal lesion." Brain 124: 2014-2027.   
  5. Pappata, S., M. Levasseur, et al. (2000). "Thalamic microglial activation in ischemic stroke detected in vivo by PET and [11C]PK1195." Neurology 55(7): 1052-1054

Inflammation

  1. Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, et al. Inflammation and Alzheimer’s disease. Neurobiol Aging 2000;21:383-421.
  2. Burns A and Zaudig M Mild Cognitive Impairment Lancet 2002 360 1963-65
  3. Emsley,HCA; Smith,CJ; Gavin,CM; Georgiou,RF; Vail,A; Barberan,EM; Hallenbeck,JM; del Zoppo,GJ; Rothwell,NJ; Tyrrell,PJ; Hopkins,SJ (2003): An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis. J.Neuroimmunol. 139, 93-101.

Imaging Parkinson’s Disease

  1. Hilker R, Voges J, Weisenbach S, Kalbe E, Burghaus L, Ghaemi M, Lehrke R, Koulousakis A, Herholz K, Sturm V, Heiss WD. Subthalamic nucleus stimulation restores glucose metabolism in associative and limbic cortices and in cerebellum: evidence from a FDG-PET study in advanced Parkinson’s disease. J Cereb Blood Flow Metab 2003 (in press)
  2. Hilker R, Voges J, Ghaemi M, Lehrke R, Rudolf J, Koulousakis A, Herholz K, Wienhard K, Sturm V, Heiss WD. Deep brain stimulation of the subthalamic nucleus does not increase the striatal dopamine concentration in parkinsonian humans. Mov Disord 2003;18:41-8.
  3. Hilker R, Voges J, Thiel A, Ghaemi M, Herholz K, Sturm V, Heiss WD. Deep brain stimulation of the subthalamic nucleus versus levodopa challenge in Parkinson’s disease: measuring the on- and off-conditions with FDG-PET. J Neural Transm 2002;109(10):1257-64.
  4. Hilker R, Klein C, Hedrich K, Ozelius LJ, Vieregge P, Herholz K, Pramstaller PP, Heiss WD. The striatal dopaminergic deficit is dependent on the number of mutant alleles in a family with mutations in the parkin gene: evidence for enzymatic parkin function in humans. Neurosci Lett 2002;323(1):50-4.
  5. Hilker R, Klein C, Ghaemi M, Kis B, Strotmann T, Ozelius LJ, Lenz O, Vieregge P, Herholz K, Heiss WD, Pramstaller PP. Positron emission tomographic analysis of the nigrostriatal dopaminergic system in familial parkinsonism associated with mutations in the parkin gene. Ann Neurol 2001;49:367-76.