University of Sydney, Sydney, Australia

[Group description | Scientific staff | Publications within DiMI ]

References

Radioligand Development

  1. Kassiou M, Mardon K, Mattner F, Katsifis A, Dikic B. (2001) Pharmacological evaluation of (+)-2-[123I]A-69024: A radioligand for in vivo studies of dopamine D1 receptors. Life Science, 69, 669-675.
  2. Kassiou M, Loc’h C, Bottlaender M, Mardon K, Ottavianni M, Coulon C, Katsifis A, Maziere B. (2002) (+)-[76Br]A-69024: A Non-benzazepine Radioligand for Studies of Dopamine D1 Receptors Using PET. Nucl. Med. Biol 29, 295-302
  3. Kassiou M, Bottlaender M, Loc’h C, Dolle F, Musachio JL, Coulon C, Ottavianni, M, Dannals RF, Maziere B. (2002) Pharmacological evaluation of a Br-76 analogue of epibatidine: A potent ligand for studying brain nicotinic acetylcholine receptors. Synapse 45, 95-104.
  4. Quinlivan M, Mattner F, Papazian V, Zhou J, Katsifis A, Emond P, Chalon S, Kozikowski A, Guilloteau D, Kassiou M. (2003) Synthesis and evaluation of iodine-123 labelled tricyclic tropanes as radioligands for the serotonin transporter. Nucl. Med. Biol 30, 741-746.
  5. Roger G, Langel B, Berset L, Bramoulle Y, Coulon C, Ottaviani M, Kassiou M, Bottlaender M, Valette H, Dolle F. (2003) Synthesis, radiosynthesis and in vivo evaluation of 5-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-1,3-dihydrobenzo-imidazol-2-[11C]one, a potent NR1A/2B subtype selective NMDA PET radiotracer. Bioorg. Med. Chem. 11, 5401-5408.
  6. Roger G, Dolle F, Langel B, Liu X, Berset L, Bramoulle Y, Coulon C, Ottaviani M, Bottlaender M, Valette H, Kassiou M (2004) Radiosynthesis of [11C]EMD-95885: A high affinity ligand for NR2B-containing NMDA receptors. Bioorg. Med. Chem. 12, 3229-3237.
  7. Dolle F, Valette H, Demphel S, Coulon C, Ottaviani M, Bottlaender M, Kassiou M (2004) Radiosynthesis and In Vivo Evaluation of [11C]Ro-647312 : A Novel NR1/2B Subtype Selective NMDA Receptor Radioligand. J. Labelled Comp. Radiopharm, 47, 911-920.
  8. Zea-Ponce Y, Mavel S, Assaad T, Emond P, Chalon S, Kruse S, Parsons SM, Giboureau N, Kassiou M, Guilloteau D. (2005) Synthesis and In Vitro Evaluation of New Benzovesamicol Analogues as Potential Imaging Probes for the Vesicular Acetylcholine Transporter. Bioorg. Med. Chem.  13, 745-753.
  9. Kassiou M, Dannals RF, Liu X, Wong DF, Ravert RT, Scheffel UA (2005) Synthesis and in vivo evaluation of a new PET radioligand for studying sigma-2 receptors. Bioorg. Med. Chem. 13, 3623-3626.
  10. James ML, Fulton RR, Henderson DJ, Eberl S, Meikle SR, Thomson S, Allan RD, Dolle F, Fulham MJ, Kassiou M. (2005) Synthesis and In Vivo Evaluation of a Novel Peripheral Benzodiazepine Receptor PET Radioligand. Bioorg. Med. Chem. 13, 6188-6194.


Imaging Microglia

  1. Pappata S., Levasseur, M., Gunn, R.N., Myers, R., Crouzel, C., Syrota, A., Jones, A., Kreutzberg, G.W., and Banati, R.B., Thalamic microglial activation in ischemic stroke detected in vivo by PET and [11C]PK11195. Neurology (2000) 55: 1052-1054..
  2. Goerres, G.W., Revesz T.,  Duncan, J., Banati, R.B., Imaging cerebral vasculitis in refractory epilepsy using [11C] (R)-PK11195 PET. Americ. J. Roentgenol. (2001) 176: 1016-1018.
  3. Cagnin, A., Brooks D.J., Kennedy, A.M., Gunn, R.N., Myers, R., Turkheimer, F.E., Jones, T., Banati, R.B. In vivo measurement of activated microglia in dementia. (2001) The Lancet 358: 461-467 (commentary: 358: 436-437).
  4. Cagnin A., Myers, R., Gunn, R.N., Lawrence A.D, Stevens, T.  MD, Kreutzberg, G.W., Jones, T, Banati, R.B. In vivo-visualisation of activated glia by [11C](R)-PK11195 PET following herpes encephalitis reveals projected neuronal damage beyond the primary focal lesion (2001) Brain 124: 2014-2027.
  5. Banati, R. B., Visualising microglial activation in vivo. Glia (2002) 40:206-217.
  6. Banati, R. B., Brain Plasticity and Microglia: Is transsynaptic glial activation in the thalamus after limb denervation linked to cortical plasticity and central sensitisation ? J. Physiol. (2002) 96:2892-99.
  7. Cagnin, A., Gerhard, A., Banati, R. B., In vivo imaging of neuroinflammation. Neuropsychopharmacology (2002) 12:581-586.
  8. Banati, R. B., Neuropathological imaging: In vivo detection of glial activation as a measure of disease and adaptive change in the brain. British Medical Bulletin (2003) 65:121-31.
  9. Gerhard A., Banati, R.B., Goerres G.W.,  Cagnin A., Myers R., Gunn R.N.,  Turkheimer F.E., Good C.,  Mathias C.,  Quinn N.,  Schwarz  J., Brooks D.J.  [11C](R) PK11195 PET imaging of microglial activation in multiple system atrophy (2003) Neurology 61:686-9.
  10. Kassiou M, Meikle SR, Banati RB (2005) Ligands for the peripheral benzodiazepine binding sites in glial cells. Brain Res. Rev. 48, 207-210.


Physics Instrumentation an Methodology

  1. S. R. Meikle, S. Eberl, R. R. Fulton, M. Kassiou, and M. J. Fulham, "The influence of tomograph sensitivity on kinetic parameter estimation in positron emission tomography imaging studies of the rat brain," Nucl Med Biol, vol. 27, pp. 617-625, 2000.
  2. K.-P. Wong, D. Feng, S. R. Meikle, and M. J. Fulham, "Simultaneous estimation of physiological parameters and the input function: in-vivo PET data," IEEE Trans Inform Technol in Biomed, vol. 5, pp. 67-76, 2001.
  3. S. R. Meikle, R. R. Fulton, S. Eberl, M. Dahlbom, K.-P. Wong, and M. J. Fulham, "An investigation of coded aperture imaging for small animal SPECT," IEEE Trans Nucl Sci, vol. 48, pp. 816-821, 2001.
  4. K.-P. Wong, D. Feng, S. R. Meikle, and M. J. Fulham, "Segmentation of dynamic PET images using cluster analysis," IEEE Trans Nucl Sci, vol. 49, pp. 200-207, 2002.
  5. R. R. Fulton, S. R. Meikle, S. Eberl, J. Pfeiffer, C. J. Constable, and M. J. Fulham, "Correction for head movements in positron emission tomography using an optical motion-tracking system," IEEE Trans Nucl Sci, vol. 49, pp. 116-123, 2002.
  6. S. R. Meikle, P. Kench, A. G. Weisenberger, R. Wojcik, M. F. Smith, S. Majewski, S. Eberl, R. R. Fulton, A. B. Rosenfeld, and M. J. Fulham, "A prototype coded aperture detector for small animal SPECT," IEEE Trans Nucl Sci, 49(5):2167-2171, 2002.
  7. K. P. Wong, S. R. Meikle, D. Feng, and M. J. Fulham, "Estimation of input function and kinetic parameters using simulated annealing: Application in a flow model," IEEE Trans Nucl Sci, 49(3):707-713, 2002.
  8. G. Weisenberger, S. S. Gleason, J. Goddard, B. Kross, S. Majewski, S. R. Meikle, M. J. Paulus, M. Pomper, V. Popov, M. F. Smith, B. L. Welch, R. Wojcik. A Restraint-Free Small Animal SPECT Imaging System with Motion Tracking. IEEE Trans Nucl Sci. vol. 52, pp. 638-644, 2005.


Small Animal Imaging

  1. Roselt P, Meikle SR, Kassiou M. (2004) The Role of Position Emission Tomography in the Discovery and Development of New Drugs; As studied in Laboratory Animals. European Journal of Drug Metabolism and Pharmacokinetics 29, 1-6.
  2. Meikle SR, Kench P, Kassiou M, Banati RB (2005) Small animal SPECT and its place in the matrix of molecular imaging technologies. Phys. Med. Biol. 50, R45-R61.