University Hospital Rigshospitalet, Copenhagen, Denmark

Neurobiology Research Unit

[Group description | Scientific staff | Publication within DiMI]

References

Data Analysis and Kinetics

  1. Liptrot M, Adams KH, Martiny L, Pinborg LH, Lonsdale MN, Olsen NV, Holm S, Svarer C, Knudsen GM: Cluster analysis in kinetic modelling of the brain: a non-invasive alternative to arterial sampling. NeuroImage (Accepted).
  2. Pinborg LH, Adams KH, Svarer C, Holm S, Hasselbalch SG, Haugbol S, Madsen J, Knudsen GM: Quantification of 5HT2A receptors in the human brain using [18F]altanserin-PET and the bolus/infusion approach. J Cereb Blood Flow Metabol 2003;23:985-96.
  3. Pinborg LH, Videbok C, Svarer C, Yndgaard S, Paulson OB, Knudsen GM: Quantification of [123I]PE2I binding to dopamine transporters with SPECT. Eur J Nucl Med 2002;29:623-31.
  4. Videbok C, Toska K, Friberg L, Holm S, Angelo HR, Knudsen GM: In vivo measurement of haloperidol affinity to dopamine D2/D3 receptors by [123I]IBZM and SPECT. J Cereb Blood Flow Metabol 2001;21:92-7
  5. Pinborg LH, Videbok C, Knudsen GM, Swahn C-G, Halldin C, Paulson OB, Lassen NA: Dopamine D2 receptor quantification in extrastriatal brain regions using [123I]epidepride with bolus/infusion. Synapse  2000;36:322-329.

Radiochemistry and Tracer Evaluation

  1. Madsen J, Merachtsaki P, Davoodpour P, Bergstrom M, Langstrom B, Andersen K, Thomsen C, Martiny L, Knudsen GM. Synthesis and biological evaluation of novel carbon-11-labelled analogues of citalopram as potential radioligands for the serotonin transporter. Bioorg Med Chem 2003;11:3447-3456.
  2. Elfving B, Bjornholm B, Knudsen GM: Interference of anaesthetics with radioligand binding in neuroreceptor studies. Eur J Nucl Med 2003;30:912-5.
  3. Elfving B, Bjornholm B, Knudsen GM: Predosing with the unlabeled inactive enantiomer as a tool for improvement of the PET signal. Synapse 2002;46:125-127.
  4. Elfving B, Bjornholm B, Ebert B, Knudsen GM: Binding characteristics of selective serotonin reuptake inhibitors with relation to emission tomography studies. Synapse 2001;41:203
  5. Videbok C, Toska K, Scheideler MA, Paulson OB, Knudsen GM: The SPECT tracer [123I]IBZM has similar affinity to dopamine D2 and D3 receptors. Synapse 2000;38:338-42
  6. Videbok C, Ott P, Paulson OB, Knudsen GM: Blood-brain barrier transport and protein binding of flumazenil and iomazenil in the rat: implications for neuroreceptor studies. J Cereb Blood Flow Metabol 1999;19:948-55.

MR Imaging Methodology

  1. Murphy PS, Rowland IJ, Viviers L, Brada M, Leach MO, Dzik-Jurasz ASK. Could assessment of the glioma methylene lipid resonance by in vivo 1H-MRS be of clinical value? Br J Radiol 2003;76:459–63
  2. Murphy PS, Leach MO, Rowland IJ. The Effects of Paramagnetic Contrast Agents on Metabolite Protons in Aqueous Solution. Phys Med Biol 2002;47:N53-59
  3. Murphy PS, Dzik-Jurasz ASK, Leach MO, Rowland IJ. The Effect of Gd-DTPA on T1-Weighted Choline Signal In Human Brain Tumours. Magn Reson Imaging 2002;20:127-30
  4. d'Arcy JA, Collins DJ, Rowland IJ, Padhani AR, Leach MO. Applications of sliding window reconstruction with cartesian sampling for dynamic contrast enhanced MRI. NMR Biomed 2002;15:174-83

Imaging Neurodegenerative Disease

  1. Pinborg LH, Videbok C, Hasselbalch SG, Sρrensen SA, Wagner A, Paulson OB, Knudsen GM: Benzodiazepine receptor quantification in Huntington’s disease with [123I]Iomazenil and SPECT. J Neuro Neurosurg Psych 2001;70:657-61. Imaging Neuroreceptors by Immunohistochemistry
  2. Aznar S, Qian Z, Knudsen GM: Non-serotonergic dorsal and median raphe projection on parvalbumin- and calbindin-containing interneurons in hippocampus and septum. Brain Res (Accepted).
  3. Aznar S, Qian Z, Shah R, Rahbek B, Knudsen GM: The 5-HT1A serotonin receptor is located on calbindin- and parvalbumin-containing neurons in the rat brain. Brain Res 2003;959:58-67.
  4. Aznar S, Knudsen GM: Serotonin induces decrease of 5-HT1A immunoreactivity in organotypic hippocampal cultures. NeuroReport 2001;12:3909-3912.