Technical University of Munich, Munich, Germany

Department of Nuclear Medicine

[Group description | Scientific staff | Publications within DiMI]

References

Instrumentation / Physics

  1. Rafecas M, Boning G, Pichler BJ, Lorenz E, Schwaiger M, Ziegler SI. Inter-crystal scatter in a dual layer, high resolution LSO-APD positron emission tomograph. Phys Med Biol. 2003; 48: 821-48.
  2. Ziegler SI, Pichler BJ, Boening G, Rafecas M, Pimpl W, Lorenz E, Schmitz N, Schwaiger M. A prototype high-resolution animal positron tomograph with avalanche photodiode arrays and LSO crystals. Eur J Nucl Med. 2001; 28: 136-43.
  3. Nekolla SG, Miethaner C, Nguyen N, Ziegler SI, Schwaiger M. Reproducibility of polar map generation and assessment of defect severity and extent assessment in myocardial perfusion imaging using positron emission tomography. Eur J Nucl Med. 1998; 25: 1313-21.

Tracer Development / Validation

  1. Wester HJ, Schottelius M, Scheidhauer K, Meisetschlager G, Herz M, Rau FC, Reubi JC, Schwaiger M. PET imaging of somatostatin receptors: design, synthesis and preclinical evaluation of a novel 18F-labelled, carbohydrated analogue of octreotide. Eur J Nucl Med Mol Imaging. 2003; 30:117-22.
  2. Haubner R, Wester HJ, Weber WA, Mang C, Ziegler SI, Goodman SL, Senekowitsch-Schmidtke R, Kessler H, Schwaiger M. Noninvasive imaging of alpha(v)beta3 integrin expression using 18F-labeled RGD-containing glycopeptide and positron emission tomography. Cancer Res. 2001; 61:1781-5.
  3. Brust P, Haubner R, Friedrich A, Scheunemann M, Anton M, Koufaki ON, Hauses M, Noll S, Noll B, Haberkorn U, Schackert G, Schackert HK, Avril N, Johannsen B. Comparison of [18F]FHPG and [124/125I]FIAU for imaging herpes simplex virus type 1 thymidine kinase gene expression. Eur J Nucl Med. 2001; 28:721-9.
  4. Haubner R, Avril N, Hantzopoulos PA, Gansbacher B, Schwaiger M. In vivo imaging of herpes simplex virus type 1 thymidine kinase gene expression: early kinetics of radiolabelled FIAU. Eur J Nucl Med 2000; 27:283-91.
  5. Wester HJ, Willoch F, Tolle TR, Munz F, Herz M, Oye I, Schadrack J, Schwaiger M, Bartenstein P. 6-O-(2-[18F]fluoroethyl)-6-Odesmethyldiprenorphine ([18F]DPN): synthesis, biologic evaluation, and comparison with [11C]DPN in humans. J Nucl Med. 2000; 41(7): 1279-86.

Experimental Imaging of Cardiovascular Biology

  1. Bengel FM, Anton M, Richter T, Simoes MV, Haubner R, Henke J, Erhardt W, Reder S, Lehner T, Brandau W, Boekstegers P, Nekolla SG, Gansbacher B, Schwaiger M. Noninvasive imaging of transgene expression using positron emission tomography in a pig model of myocardial gene transfer. Circulation. 2003; 108: 2127-2133.
  2. Bengel FM, Anton M, Avril N, Brill T, Nguyen N, Haubner R, Gleiter E, Gansbacher B, Schwaiger M. Uptake of radiolabeled 2'-fluoro-2'- deoxy-5-iodo-1-beta-D-arabinofuranosyluracil in cardiac cells after adenoviral transfer of the herpesvirus thymidine kinase gene: the cellular basis for cardiac gene imaging. Circulation. 2000; 102:948-50.
  3. Egert S, Nguyen N, Schwaiger M. Contribution of alpha-adrenergic and beta-adrenergic stimulation to ischemia-induced glucose transporter (GLUT) 4 and GLUT1 translocation in the isolated perfused rat heart. Circ Res. 1999; 84:1407-15.

Clinical Cardiovascular Molecular Imaging

  1. Klein C, Nekolla SG, Bengel FM, Momose M, Sammer A, Haas F, Schnackenburg B, Delius W, Mudra H, Wolfram D, Schwaiger M. Assessment of myocardial viability with contrast-enhanced magnetic resonance imaging: comparison with positron emission tomography. Circulation. 2002; 105:162-7.
  2. Ibrahim T, Nekolla SG, Schreiber K, Odaka K, Volz S, Mehilli J, Guthlin M, Delius W, Schwaiger M. Assessment of coronary flow reserve: comparison between contrast-enhanced magnetic resonance imaging and positron emission tomography. J Am Coll Cardiol. 2002; 39:864-70.
  3. Bengel FM, Ueberfuhr P, Schiepel N, Nekolla SG, Reichart B, Schwaiger M. Effect of sympathetic reinnervation on cardiac performance after heart transplantation. N Engl J Med. 2001; 345:731-8.
  4. Munch G, Nguyen NT, Nekolla S, Ziegler S, Muzik O, Chakraborty P, Wieland DM, Schwaiger M. Evaluation of sympathetic nerve terminals with [(11)C]epinephrine and [(11)C]hydroxyephedrine and positron emission tomography. Circulation. 2000; 101:516-23.
  5. Guethlin M, Kasel AM, Coppenrath K, Ziegler S, Delius W, Schwaiger M. Delayed response of myocardial flow reserve to lipid-lowering therapy with fluvastatin. Circulation. 1999; 99:475-81.

Molecular Imaging in Neuroscience

  1. Drzezga A, Lautenschlager N, Siebner H, Riemenschneider M, Willoch F, Minoshima S, Schwaiger M, Kurz A. Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer's disease: a PET follow-up study. Eur J Nucl Med Mol Imaging. 2003; 30(8): 1104-13.
  2. Boecker H, Ceballos-Baumann AO, Bartenstein P, Dagher A, Forster K, Haslinger B, Brooks DJ, Schwaiger M, Conrad B. A H (2)(15)O positron emission tomography study on mental imagery of movement sequences--the effect of modulating sequence length and direction. Neuroimage. 2002; 17(2): 999-1009.
  3. Drzezga A, Darsow U, Treede R, Siebner H, Frisch M, Munz F, Weilke F, Ring J, Schwaiger M, Bartenstein P. Central activation by histamine-induced itch: analogies to pain processing: a correlational analysis of O-15 H(2)O positron emission tomography studies. Pain. 2001; 92(1-2): 295-305.
  4. Lautenschlager NT, Riemenschneider M, Drzezga A, Kurz AF. Primary degenerative mild cognitive impairment: study population, clinical, brain imaging and biochemical findings. Dement Geriatr Cogn Disord. 2001; 12(6): 379-86.
  5. Arnold S, Berthele A, Drzezga A, Tolle TR, Weis S, Werhahn KJ, Henkel A, Yousry TA, Winkler PA, Bartenstein P, Noachtar S. Reduction of benzodiazepine receptor binding is related to the seizure onset zone in extratemporal focal cortical dysplasia. Epilepsia. 2000; 41(7): 818-24.