Research Centre Jülich, Jülich, Germany

Institute of Medicine (Molecular Neuroimaging Laboratory)

[Group description | Scientific staff | Publications within DiMI]

References

Receptor Imaging

  1. Bauer, A.; Holschbach, M.H.; Meyer, P.T.; Boy, C.; Herzog, H.; Olsson, R.A.; Coenen, H.H.; Zilles, K.: In vivo imaging of adenosine A1 receptors in the human brain with [18F]CPFPX and positron emission tomography. Neuroimage 2003; 19, 1760-1769.
  2. Bauer, A.; Holschbach, M.H.; Cremer, M.; Weber, S.; Boy, C.; Shah, N.J.; Olsson, R.A.; Halling, H.; Coenen, H.H.; Zilles, K.; Evaluation of 18F-CPFPX, a Novel Adenosine A1 Receptor Ligand: In Vitro Autoradiography and High Resolution Small Animal PET. J Nucl Med 2003; 44, 1682-1689.
  3. Meyer, P.T.; Bier, D.; Holschbach, M.H.; Cremer, M.; Tellmann, L.; Bauer, A.: In vivo imaging of rat brain A1 adenosine receptor occupancy by caffeine. Eur J Nucl Med Mol Imaging 2003; 30(10), 1440.
  4. von Hörsten, S.; Schmitt, I.; Nguyen, H.P.; Holzmann, C.; Schmidt, T.; Walther, T.; Bader, M.; Pabst, R.; Kobbe, P.; Krotova, J.; Stiller, D.; Kask, A.; Vaarmann, A.; Rathke-Hartlieb, S.; Schulz, J.B.; Grasshoff, U.; Bauer, A.; Li, X.J.; Riess, O.: Transgenic rat model of Huntington’s disease. Hum Mol Gen 2003; 12(6), 617-624.
  5. Härtig, W.; Bauer, A.; Brauer, K.; Grosche, J.; Hortobagyi, T.; Penke, B.; Schliebs, R.; Harkany, T.: Functional recovery of cholinergic basal forebrain neurons under disease conditions: Old problems, new solutions? Rev Neurosci 2002; 13, 95-165.

Ligand Development

  1. Holschbach,M. H.; Wutz,W.; Olsson,R. A. Synthesis of 2-benzyl-2H-pyrazole-3,4-diamine dihydrochloride. Tetrahedron 2003; 44, 41 – 43.
  2. Holschbach,M.H.; Wutz,W.; Schüller,M.; Bier,D.; Coenen,H. H. Tritium-labelled 8-cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine ([3H]CPFPX), a potent and selective antagonist for the A1 adenosine receptor. J labelled compd rad 2003; 46: 365-372.
  3. Holschbach,M. A.; Olsson,R. A. Applications of adenosine receptor ligands in medical imaging by positron emission tomography Curr pharm design 2002; 8, 26: 2345 – 2352.
  4. Holschbach,M.H.; Olsson,R. A.; Bier,D.; Wutz,W.; Schüller,M.; Palm,B.; Coenen,H. H. Radiosynthesis and evaluation of n.c.a. 8-cyclopentyl-3-(3-[18F]fluoroprophyl)-l-propylxynthine ([18F]CPFPX), a potent and selective A1-adenosine receptor antagonist J med chem 2002; 45:5150 – 5156.

Instrumentation Physics PET

  1. Buchholz, H. G., Herzog, H., Förster, G. J., Reber, H., Nickel, O., Rösch, F., Bartenstein, P. PET imaging with yttrium-86: comparison of phantom measurements acquired with different PET scanners before and after applying background subtraction. Eur J Nucl Med Mol Imaging 2003; 30:716-720.
  2. Herzog H, Tellman L, Qaim SM, Spellerberg S, Schmid A, Coenen HH. PET quantitation and imaging of the non-pure positron-emitting iodine isotope 124I. Appl Radiat Isot. 2002; 56(5):673-9.
  3. Kemna LJ, Posse S, Tellmann L, Schmitz T, Herzog H. Interdependence of regional and global cerebral blood flow during visual stimulation: an O-15-butanol positron emission tomography study. J Cereb Blood Flow Metab. 2001; 21(6):664-70.
  4. Weber, S.; Bauer, A.; Herzog, H.; Kehren, F.; Mühlensiepen, H.; Vogelbruch, J.; Coenen, H. H.; Zilles, K.; Halling, H. Recent results of the TierPET scanner IEEE T Nucl Sci 2000; 47, 4, 1665 – 1669.
  5. Weber S, Terstegge A, Herzog H, Reinartz R, Reinhart P, Rongen F, Muller-Gartner HW, Halling H. The design of an animal PET: flexible geometry for achieving optimal spatial resolution or high sensitivity. IEEE Trans Med Imaging. 1997 Oct; 16(5):684-9.

Instrumentation Physics MRT

  1. Shah NJ, Neeb H, Zaitsev M, Steinhoff S, Kircheis G, Amunts K, Häussinger D, Zilles K. Quantitative T1 Mapping of Hepatic Encephalopathy using Magnetic Resonance Imaging. Hepatology (in press)
  2. Shah NJ, Zaitsev M, Steinhoff S, Zilles K. A new method for fast multislice T(1) mapping. Neuroimage. 2001;14(5):1175-85.
  3. Steinhoff S, Zaitsev M, Zilles K, Shah NJ. Fast T(1) mapping with volume coverage. Magn Reson Med. 2001;46(1):131-40.
  4. Zaitsev M, Zilles K, Shah NJ. Shared k-space echo planar imaging with keyhole. Magn Reson Med. 2001;45(1):109-17.
  5. Shah NJ, Unlu T, Wegener HP, Halling H, Zilles K, Appelt S. Measurement of rubidium and xenon absolute polarization at high temperatures as a means of improved production of hyperpolarized (129)Xe. NMR Biomed. 2000;13(4):214-9.