University of Oslo, Oslo, Norway

Institute for Nutrition Research and Institute of Immunology, Faculty of Medicine

[Scientific staff | Publications within DiMI | References]

Group Description

The Oslo group has its main interest in studying gene regulation in relation to nutrition and disease. The groups involved from the University of Oslo have a long-standing expertise in transgenic mice technology such as the production and application of luciferase based reporter mice for optical imaging and genetically altered mouse models for inflammatory disease and cancer rejection. Regulation of gene expression is at the center of our understanding of normal development as well as most, if not all types of diseases. The need to follow the temporal and spatial patterns of expression of individual genes in vivo is therefore obvious. One of the transgenic reporter models developed by the group led by Professor Rune Blomhoff is a model whose expression of luciferase is controlled by three copies of the binding site for the transcription factor NFkB. [read more]