University of Durham, Durham, United Kingdom
Department of Chemistry
There are three academic groups (Parker/Williams and Beeby) in Durham (Chemistry is 5*A rated) that each have over 10 years experience in devising new chemistry for de novo imaging probes. At present the work is restricted to studies in cells, and in vitro probes have been devised for a range of bioactive species, mostly based upon the modulation of lanthanide luminescence. Within the University a new Interdisciplinary Centre for Bioactive Chemistry has been formed (5 million euros invested in 2004 for space/equipment) with Optical Imaging Probes a key element in this initiative. This work has secured national and regional funds supporting collaborative projects with colleagues in Biological and Biomedical Sciences in the University. Durham is also serving as a coordinating centre in part of the approved NoE ‘EMIL’, and through other established European contacts (e.g. CIS-Bio/France Amersham Health/Biosciences, UK). The groups will develop the synthesis, and evaluation of new luminescent imaging agents for subsequent applications, focusing initially on selected assays that may aid the early detection of inflammation.